Pamoic Acid CAS 130-85-8

1. Pamoic acid (tseem hu ua embonic acid) yog ib qho naphthoic acid derivative feem ntau siv los ua "inactive" tshuaj tiv thaiv los ua pamoate ntsev, uas ua rau lub sijhawm ntev ntawm cov tshuaj nquag (xws li hauv hydroxyzine pamoate, imipramine pamoate, thiab pyrantel pamoate) los ntawm kev txo lawv cov solubility.
2. Pamoic acid CAS 130-85-}8 tau raug txheeb xyuas tias yog ib qho muaj zog agonist ntawm tus menyuam ntsuag G protein-coupled receptor GPR35 (EC50 ntawm 79 nM), ua kom cov kev taw qhia qis qis xws li ERK1/2 phosphorylation thiab -arrestin2 cov tshuaj muaj txiaj ntsig rau cov tshuaj ntsev.
3. Pamoic acid nthuav tawm los tiv thaiv- cov khoom ua mob los ntawm inhibiting HMGB1·CXCL12-elicited chemotaxis, txo cov leukocyte recruitment (tshwj xeeb yog neutrophils) thiab cov kab mob hauv cov hlab ntsws hauv cov qauv murine ntawm Pseudomonas aeruginosa pneumonia, qhia txog qhov muaj peev xwm kho cov kab mob ua pa.
4. Cov kws tshawb fawb siv Pamoic acid CAS 130-85-8 hauv kev tshawb fawb txog kev xa tshuaj, qhov uas nws tsim hydrophobic ion-pairs nrog cov khoom xyaw tshuaj nquag (APIs) hauv cov polymeric nanoparticle cores (piv txwv li, PLA-PEG systems), ua kom tswj tau cov tshuaj kinetics thiab txhim kho biocapavulated.

1. Pamoic acid yuav tsum tau muab cia rau hauv lub thawv kaw nruj nreem nyob rau hauv qhov chaw txias, qhuav, thiab zoo - qhov cua qhov chaw ntawm 2-8℃(tub yees), tiv thaiv lub teeb thiab noo noo kom ruaj khov.
2. Pamoic acid CAS 130-85-8 yog cais nrog GHS lub teeb liab lo lus "Ceeb toom" thiab cov nqe lus txaus ntshai H315 (Ua rau tawv nqaij khaus), H319 (Ua rau qhov muag khaus), thiab H335 (Tej zaum yuav ua rau ua pa ua pa) raws li cov ntaub ntawv kev nyab xeeb ntawm cov khoom siv.
3. Cov neeg ua haujlwm yuav tsum hnav cov tshuaj lom neeg- cov hnab looj tes tiv thaiv, nruj nruj tsom iav kev nyab xeeb nrog sab - cov ntaub thaiv npog raws li EN166 (EU) lossis NIOSH (US), thiab cov khaub ncaws tiv thaiv tsis zoo thaum tuav cov khoom no, ua kom muaj cua txaus hauv chaw ua haujlwm.
4. Khaws kom deb ntawm qhov tsis sib haum Pamoic acid CAS 130-85-8 cov ntaub ntawv xws li cov tshuaj muaj zog oxidizing; zam kev tsim cov plua plav thiab aerosols, tiv thaiv kev sib cuag ntawm daim tawv nqaij thiab lub qhov muag, thiab nco ntsoov tias cov compound yog insoluble hauv dej, ACN, MeOH, thiab DCM tab sis soluble hauv DMSO (Ntau dua lossis sib npaug ntawm 40 mg / mL) thiab pyridine .

1. Tshem tawm qhov chaw nchuav, ua kom muaj cua txaus, tshem tawm tag nrho cov khoom siv hluav taws xob, thiab hnav cov cuab yeej tiv thaiv tus kheej nrog rau cov tshuaj lom neeg - cov hnab looj tes tiv thaiv, tsom iav kev nyab xeeb, thiab lub tshuab nqus pa uas tsim nyog thaum pamoic acid tso tawm, tshem cov neeg ua haujlwm mus rau thaj chaw nyab xeeb.
2. Sau Pamoic acid CAS 130-85-8 los ntawm kev cheb lossis nqus tsev yam tsis tsim cov plua plav uas siv cov cuab yeej tsis muaj teeb meem, lossis nqus nrog cov khoom siv tsis zoo xws li diatomite lossis universal binders, thiab muab tso rau hauv cov thawv kaw tsim nyog rau kev pov tseg.
3. Tsis txhob tsim cov huab cua thaum lub sij hawm ntxuav kom tsis txhob ua pa; tiv thaiv cov khoom los ntawm kev nkag mus rau hauv cov dej ntws los yog cov dej hauv chav dej raws li kev tawm mus rau ib puag ncig yuav tsum zam.
4. Tshem tawm cov khoom siv Pamoic acid CAS 130-85-8 pov tseg raws li cov kev cai hauv zos, xeev, thiab tseem fwv ib puag ncig los ntawm kev tso cai rau kev puas tsuaj los yog kev tswj cov incineration nrog flue gas txhuam; Nco ntsoov tias cov khoom tsis raug cais raws li cov khoom siv phom sij rau kev thauj mus los (DOT / IATA).

1. Pamoic acid yog combustible nrog ib tug flash point ntawm 322.4℃thiab boiling point ntawm 586.2℃ntawm 760 mmHg; Nyob rau hauv cov xwm txheej hluav taws kub, cov khoom tsim kev puas tsuaj muaj xws li cov pa phem ntawm cov pa roj carbon monoxide, carbon dioxide, thiab lwm cov pa roj carbon monoxide.
2. Siv Pamoic acid CAS 130-85-8 chemical qhuav hmoov, carbon dioxide, los yog dej cawv-resistant ua npuas ncauj los tua hluav taws nrog cov khoom; Tsis txhob siv lub dav hlau dej ncaj qha vim nws yuav tawg cov khoom tawg.
3. Cov neeg tua hluav taws yuav tsum hnav nws tus kheej- muaj cov cuab yeej ua pa hauv siab- thov, MSHA/NIOSH tau pom zoo, thiab cov iav tiv thaiv tag nrho thaum tuav cov pamoic acid hlawv vim muaj kev puas tsuaj rau cov pa roj uas tsim los ntawm thermal decomposition .
4. Thaum lub sij hawm combustion, tej zaum yuav emit irritant thiab toxic fumes; txav cov thawv los ntawm qhov chaw tua hluav taws yog tias muaj kev nyab xeeb ua li ntawd, txias cov thawv ntim nrog cov tshuaj tsuag dej los ntawm qhov chaw tiv thaiv, thiab muaj cov hluav taws kub los tiv thaiv ib puag ncig thiab muaj kuab paug.