N-Acetyl-L-leucine CAS 1188-21-2

1. N-Acetyl-L-leucine yog ib qho acetylated derivative ntawm cov amino acid leucine thiab tab tom tsim los ua tshuaj (levacetylleucine) rau cov kab mob neurological, nrog kev pom zoo siv hauv Fabkis rau vertigo (Tanganil) thiab tsis ntev los no FDA pom zoo (Aqneural disease).
2. N-Acetyl-L-leucine CAS 1188-21-2 ua raws li cov khoom siv uas hla L-type amino acid transporter (LAT1) siv los ntawm leucine thiab hloov pauv los ntawm cov organic anion transporters (OAT1, OAT3) thiab monocarboxylate cov ntaub so ntswg xa mus rau hauv cov ntaub so ntswg (OAT1, OAT3) thiab monocarboxylate. cov txheej txheem metabolic.
3. N-Acetyl-L-leucine tau pom cov txiaj ntsig neuroprotective hauv cov qauv ua ntej, txhim kho kev ua haujlwm zoo thiab txo qis cortical cell tuag thiab neuroinflammation tom qab mob hlwb raug mob hauv cov nas los ntawm kev kho ib nrab ntawm autophagy flux .
4. Kev sim tshuaj ntsuam xyuas tau pom tias muaj kev txo qis hauv cov tsos mob neurologic thiab cov tsos mob hauv Niemann- Xaiv kab mob hom C (SARA tau qhab nia txhim kho ntawm -1.97 cov ntsiab lus vs. -0.60 nrog cov placebo), thiab cov kev tshawb fawb tsis tu ncua yog ntsuas kev ua tau zoo hauv ataxia-telangiectasia, GM2 gangliosides, thiab lwm yam kab mob.

1. N-Acetyl-L-leucine hmoov yuav tsum khaws cia ntawm -20℃kom ruaj khov mus ntev (txog 3 xyoos) lossis ntawm 4℃txog li 2 xyoos; cov kev daws teeb meem yuav tsum tau khaws cia ntawm -80℃txog li 6 lub hlis lossis -20℃rau 1 lub hlis, tiv thaiv los ntawm ya raws.
2. N-Acetyl-L-leucine CAS 1188-21-2 yog soluble hauv DMSO (Ntau dua lossis sib npaug li 20 mg/mL) thiab ethanol (34 mg/mL) tab sis insoluble hauv dej; Cov kev daws teeb meem yuav tsum tau npaj rau hauv cov vials kaw nruj nreem thiab siv nyob rau hauv 1 lub hlis ntawm -20 degree, tsis txhob rov qab khov-thaw mus.
3. Levacetylleucine tuaj yeem ua rau embryo-fetal raug mob thaum cev xeeb tub raws li kev tshawb fawb tsiaj; Cov poj niam uas muaj peev xwm yug me nyuam yuav tsum siv cov tshuaj tiv thaiv zoo thaum kho thiab rau 7 hnub tom qab koob tshuaj kawg.
4. N-Acetyl-L-leucine CAS 1188-21-2 inhibits P-glycoprotein (P-gp) efflux transporter; ceev faj yog qhia thaum coadministered nrog P-gp substrates (piv txwv li, digoxin, dabigatran, afatinib) raws li qib yuav nce, yuav tsum tau saib xyuas rau kev phiv.

1. Tshem tawm qhov chaw nchuav, ua kom muaj cua txaus, thiab hnav cov cuab yeej tiv thaiv tus kheej nrog rau cov tshuaj lom neeg- cov hnab looj tes tiv thaiv, tsom iav tiv thaiv, thiab lub tshuab ua pa uas tsim nyog thaum N-Acetyl-L-leucine tawm.
2. Sau N-Acetyl-L-leucine CAS 1188-21-2 los ntawm kev cheb los yog nqus cov plua plav tsis tsim cov plua plav siv cov cuab yeej uas tsis muaj hluav taws xob, thiab muab tso rau hauv cov thawv kaw tsim nyog rau kev pov tseg.
3. Tsis txhob tsim cov huab cua thaum lub sij hawm ntxuav kom tsis txhob ua pa; tiv thaiv cov khoom los ntawm kev nkag mus rau hauv cov dej ntws los yog cov dej hauv chav dej raws li kev tso tawm mus rau ib puag ncig yuav tsum zam.
4. Pov tseg cov ntaub ntawv khaws tseg raws li hauv zos, xeev, thiab tseem fwv cov kev cai ib puag ncig los ntawm kev tso cai los ntawm kev puas tsuaj los yog kev tswj cov incineration; cov khoom siv tsis raug cais raws li cov khoom tsim kev puas tsuaj rau kev thauj mus los (IATA, IMDG, DOT).

1. N-Acetyl-L-leucine tsis raug cais raws li cov nplaim taws heev tab sis tuaj yeem decompose nyob rau hauv hluav taws kub, emitting fumes xws li carbon monoxide, carbon dioxide, thiab nitrogen oxides (NOx).
2. Siv N-Acetyl-L-leucine CAS 1188-21-2 tshuaj tsuag dej, tshuaj qhuav hmoov, carbon dioxide, los yog cawv-resistant ua npuas ncauj los tua hluav taws uas muaj cov khoom.
3. Cov neeg tua hluav taws yuav tsum hnav tus kheej- muaj cov cuab yeej ua pa hauv siab- thov, MSHA/NIOSH tau pom zoo, thiab cov iav tiv thaiv tag nrho thaum tuav cov hlawv N-Acetyl-L-leucine vim yog cov pa roj carbon monoxide tsim los ntawm thermal decomposition.
4. Thaum lub sij hawm combustion, tej zaum yuav emit irritant thiab toxic fumes; txav cov thawv los ntawm qhov chaw tua hluav taws yog tias muaj kev nyab xeeb ua li ntawd, txias cov thawv ntim nrog cov tshuaj tsuag dej los ntawm qhov chaw tiv thaiv, thiab muaj hluav taws los tiv thaiv ib puag ncig.