Macitentan CAS 441798-33-0

1. Macitentan yog ib qho kev hais lus active dual endothelin receptor antagonist (ERA) uas thaiv kev khi ntawm endothelin-1 (ET-1) rau ob qho tib si ETA thiab ETB receptors, yog li txo qis vasoconstriction, fibrosis, proliferation, thiab o ntawm cov neeg mob pulmonary arterial hypertension (PAH).
2. Macitentan CAS 441798-33-0 yog qhia rau kev kho mob pulmonary arterial hypertension (PAH, WHO Group 1) kom ncua kev kis kab mob, uas suav nrog kev txo qis kev pheej hmoo ntawm kev tuag, kev mus pw hauv tsev kho mob rau PAH, kev kho mob tsis zoo, thiab xav tau kev kho mob parenteral prostanoid .
3. Macitentan yog metabolized nyob rau hauv daim siab ntawm CYP3A4 enzyme mus rau hauv ib tug loj pharmacologically active metabolite, ACT-132577, uas muaj txhawb rau nws sustained kho cov nyhuv nrog ib nrab-lub neej ntev (kwv yees li 48 teev) tshaj li cov tshuaj niam txiv.
4. Hauv kev tshawb fawb preclinical, Macitentan CAS 441798-33-0 tau pom cov ntaub so ntswg-tim cov khoom vim nws cov lipophilicity siab, tiv thaiv kev puas tsuaj ntawm lub cev kawg (xws li lub raum vascular hypertrophy) hauv cov qauv ntshav qab zib thiab txhim kho txoj sia nyob hauv pulmonary hypertensive nas.

1. Macitentan yuav tsum tau muab cia rau hauv lub thawv kaw nruj nreem ntawm chav tsev kub (qis dua 30 degree), tiv thaiv lub teeb thiab noo noo, thiab khaws cia kom deb ntawm tshav ntuj ncaj qha thiab tshav kub.
2. Rau ntev -lub sij hawm ruaj ntseg, Macitentan CAS 441798-33-0 hmoov yog ruaj khov mus txog 3 xyoos ntawm -20℃lossis 2 xyoos ntawm 4 degree; Cov khoom lag luam hauv cov kuab tshuaj yuav tsum tau khaws cia ntawm -20℃txog li 1 lub hlis lossis ntawm -80℃txog li 6 lub hlis, tsis txhob rov qab khov-thaw mus.
3. Macitentan raug cais raws li cov khoom siv phom sij uas muaj peev xwm teratogenic cuam tshuam; Nws yog tshuaj lom yog tias nqos tau, qhov mob me me mus rau qhov hnyav rau ntawm daim tawv nqaij thiab qhov muag, thiab tej zaum yuav ua rau qhov muag puas tsuaj loj (R41). Cov neeg ua haujlwm tuav Macitentan yuav tsum hnav cov tshuaj lom neeg- cov hnab looj tes tiv thaiv roj hmab, NIOSH/MSHA- pom zoo ua pa pa, thiab tsom iav kev nyab xeeb tshuaj nrog sab - cov ntaub thaiv npog .
4. Macitentan CAS 441798-33-0 yog ib qho tshuaj active ingredient uas yuav tsum tau tsuas yog ua los ntawm cov neeg ua hauj lwm kawm paub txog muaj zog active tshuaj cov khoom xyaw; nws yuav tsum tau khaws cia kom deb ntawm cov khoom siv tsis sib xws xws li cov neeg ua haujlwm oxidizing muaj zog, cov kua qaub muaj zog, thiab cov hauv paus muaj zog los tiv thaiv kev puas tsuaj.

1. Tshem tawm qhov chaw nchuav, ua kom muaj cua txaus, thiab hnav cov cuab yeej tiv thaiv tus kheej nrog rau cov tshuaj lom neeg- cov hnab looj tes tiv thaiv roj hmab, tshuaj tiv thaiv tsom iav, thiab NIOSH/MSHA- pom zoo ua pa thaum Macitentan tso tawm.
2. Sau Macitentan CAS 441798-33-0 los ntawm kev cheb lossis nqus plua plav yam tsis tsim cov plua plav uas siv cov cuab yeej tsis muaj teeb meem; rau cov kev daws teeb meem, nqus nrog cov hmoov zoo ua kua-binding cov ntaub ntawv xws li diatomite lossis universal binders.
3. Tsis txhob tsim cov huab cua thaum lub sij hawm ntxuav kom tsis txhob ua pa; decontaminate qhov chaw thiab cov khoom siv los ntawm kev txhuam nrog cawv, thiab tiv thaiv Macitentan los ntawm kev nkag mus rau hauv cov dej los yog dej hauv chav dej.
4. Muab pov tseg cov khoom pov tseg raws li cov kev cai hauv zos, xeev, thiab tseem fwv ib puag ncig; Macitentan raug suav hais tias tsis yog - muaj kev phom sij rau kev thauj mus los (DOT, IATA, IMDG) tab sis yuav tsum muaj kev tswj xyuas pov tseg kom raug.

1. Macitentan tsis raug cais raws li cov nplaim hluav taws kub heev tab sis tuaj yeem decompose nyob rau hauv qhov hluav taws kub, emitting fumes lom xws li carbon monoxide, carbon dioxide, thiab nitrogen oxides (NOx).
2. Siv cov tshuaj tsuag dej, tshuaj qhuav hmoov, carbon dioxide, los yog cawv- ua npuas ncauj los tua hluav taws uas muaj Macitentan; Tsis txhob siv lub dav hlau dej ncaj qha raws li Macitentan CAS 441798-33-0 tuaj yeem tawg cov khoom tawg.
3. Cov neeg tua hluav taws yuav tsum hnav tus kheej- muaj cov cuab yeej ua pa hauv siab- thov, MSHA/NIOSH tau pom zoo, thiab cov iav tiv thaiv tag nrho thaum tuav cov hluav taws kub Macitentan vim yog cov pa phem uas tsim los ntawm thermal decomposition .
4. Thaum lub sij hawm combustion, Macitentan yuav emit irritant thiab toxic fumes; muaj cov hluav taws kub nyhiab los tiv thaiv ib puag ncig thiab tsis txhob tso rau hauv cov dej.