Azathioprine CAS 446-86-6

1. Azathioprine feem ntau yog siv los ua ib qho tshuaj tiv thaiv kab mob antimetabolite rau kev tiv thaiv kev tsis lees paub hauv lub raum homotransplantation thiab rau kev tswj cov kab mob rheumatoid mob caj dab kom txo tau cov tsos mob thiab cov tsos mob.
2. Azathioprine CAS 446-86-6 kuj tau qhia rau ntau yam ntawm autoimmune thiab inflammatory mob xws li mob hnyav rheumatoid mob caj dab, autoimmune kab mob siab, kab mob lupus erythematosus, kab mob plab hnyuv (Crohn's disease thiab ulcerative colitis), myasthenia.
3. Nyob rau hauv dermatology, azathioprine yog siv los kho cov kab mob immunobullous, generalized eczematous disorders, photodermatoses, thiab lwm yam deilitating tawv nqaij tej yam kev mob uas Azathioprine CAS 446-86-6 ua los ntawm disrupting nucleic acid synthesis thiab cuam tshuam nrog T-cell activation.
4. Azathioprine ua haujlwm raws li cov tshuaj uas tau hloov mus rau 6-mercaptopurine (6-MP), uas tom qab ntawd metabolized rau hauv 6-thioguanine nucleotides (6-TGNs) uas koom nrog hauv DNA thiab nthuav tawm cov tshuaj tiv thaiv kab mob thiab kev tiv thaiv kab mob los ntawm kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob.

1. Azathioprine yuav tsum tau muab cia rau hauv lub thawv kaw nruj nreem nyob rau hauv ib qho chaw inert, tiv thaiv los ntawm lub teeb thiab oxidation, nyob rau hauv txias txias (2-8 degree) rau stability, raws li Azathioprine CAS 446-86-6 yog rhiab heev rau huab cua thiab tej zaum yuav decompose ntawm 243-244 degree.
2. Cov khoom lag luam yog cov neeg paub txog cov kab mob carcinogen cais nrog cov lus txaus ntshai suav nrog kev mob pob txha pob txha, muaj kev pheej hmoo ntawm kev kis kab mob, kab mob siab mob siab, kab mob biliary stasis, thiab nqa ib lub BOXED WARNING rau malignancy nrog rau tom qab- hloov lymphoma thiab hepatosplenic T-cell lymphoma (HSTCL) kab mob hauv cov neeg mob.
3. Cov neeg ua haujlwm yuav tsum hnav cov tshuaj lom neeg- hnab looj tes tiv thaiv, NIOSH- pom zoo ib nrab- lub ntsej muag lub ntsej muag nrog cov lim dej ua ke (organic vapor/acid gas/HEPA), tsom iav kev nyab xeeb, thiab cov khaub ncaws tiv thaiv tsis zoo thaum tuav azathioprine, vim nws yog ib qho tshuaj lom neeg muaj kev nyab xeeb.
4. Tsis txhob nqus cov pa Azathioprine CAS 446-86-6 ntawm cov plua plav, ua kom muaj cua txaus hauv cov chaw ua haujlwm (xws li cov tshuaj fume hood), thiab ntxuav cov kab mob nrog 5% ammonium hydroxide tom qab siv xab npum thiab dej; Kev ntsuam xyuas caj ces rau TPMT thiab NUDT15 qhov tsis txaus yuav tsum raug txiav txim siab ua ntej pib kho vim muaj kev pheej hmoo ntawm myelosuppression hnyav rau cov neeg mob uas txo qis kev ua haujlwm enzyme.

1. Cais Azathioprine CAS 446-86-6 thaj chaw nchuav, ua kom muaj cua txaus, thiab hnav cov cuab yeej tiv thaiv tus kheej nrog rau tus kheej- muaj cov cuab yeej ua pa thaum tso azathioprine; tshem tawm cov neeg ua haujlwm tsis tseem ceeb thiab kaw cov khaub ncaws uas tsis huv hauv cov hnab yas vapor nruj.
2. Rau cov nchuav me me, dampen cov khoom siv nrog 5% ammonium hydroxide, tom qab ntawd hloov cov khoom dampened mus rau lub thawv tsim nyog siv cov ntawv nqus dej Azathioprine CAS 446-86-6 dampened nrog 5% ammonium hydroxide kom khaws cov khoom seem.
3. Tsis txhob tsim cov huab cua thaum lub sij hawm ntxuav kom tsis txhob ua pa; decontaminate tag nrho cov kab mob ntawm qhov chaw nrog 5% ammonium hydroxide tom qab ntxuav nrog xab npum thiab dej, thiab tsis txhob rov qab mus rau hauv cheeb tsam kom txog thaum kuaj xyuas kom zoo.
4. Tshem tawm cov khoom siv Azathioprine CAS 446-86-6 pov tseg raws li hauv zos, xeev, thiab tseem fwv cov kev cai ib puag ncig uas muaj kev phom sij, lees paub tias azathioprine yog ib qho zoo rau tib neeg cov kab mob carcinogen thiab xav tias tsiaj carcinogen yuav tsum muaj cov txheej txheem pov tseg tshwj xeeb.

1. Azathioprine tej zaum combustible txawm tias flash point cov ntaub ntawv tsis muaj; Nws decomposes ntawm 243-244℃thiab thaum rhuab mus rau decomposition emits cov pa phem ntawm nitrogen oxides (NOx) thiab sulfur oxides (SOx).
2. Siv Azathioprine CAS 446-86-6 qhuav tshuaj hmoov, carbon dioxide, los yog Halon extinguishers los tswj cov hluav taws kub nrog cov khoom; Cov tshuaj tsuag dej tuaj yeem siv los ua kom cov thawv txias txias tab sis tsis txhob tso dej ncaj qha rau ntawm cov khoom siv hluav taws xob.
3. Cov neeg tua hluav taws yuav tsum hnav tus kheej- muaj cov cuab yeej ua pa hauv siab- thov, MSHA / NIOSH tau pom zoo, thiab cov iav tiv thaiv tag nrho thaum tuav cov kub hnyiab azathioprine Azathioprine CAS 446-86-6 vim muaj kev puas tsuaj rau cov pa roj xws li cov pa roj carbon monoxide, carbon dioxide, SO NOx decomposition.
4. Azathioprine tuaj yeem ua rau cov kua qaub thiab tsis sib haum nrog isocyanates, peroxides, phenols, epoxides, anhydrides, acid halides, thiab muaj zog txo cov neeg ua haujlwm (uas tuaj yeem tsim cov nplaim hluav taws xob lossis hydrogen sulfide); muaj hluav taws kub los tiv thaiv ib puag ncig.