1-Methyl-D-tryptophan CAS 110117-83-4

1. 1-Methyl-D-tryptophan feem ntau yog siv hauv kev tshawb fawb biomedical raws li lub zog immunomodulatory tus neeg sawv cev uas thim rov qab tiv thaiv kab mob los ntawm kev tsom mus rau tryptophan catabolism txoj hauv kev, tshwj xeeb ua haujlwm raws li inhibitor ntawm indoleamine 2,3-dioxygenase (IDO) ntawm 7 μICO.
2. 1-Methyl-D-tryptophan CAS 110117-83-4 (tseem hu ua Indoximod) tau nkag mus rau Phase III kev sim tshuaj raws li cov tshuaj sib tw rau kev kho mob melanoma hauv kev sib xyaw nrog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, qhov uas nws tiv thaiv T-cell anergy los ntawm kev ua kom muaj zog ntau dhau ntawm cov hlwb thiab DO. kev tiv thaiv kab mob.
3. 1-Methyl-D-tryptophan yog ua hauj lwm hauv peptide synthesis thiab natural khoom npaj, tshwj xeeb tshaj yog nyob rau hauv Pictet-Spengler cov tshuaj tiv thaiv ntawm tryptophan esters nrog aldehydes los npaj macroline alkaloids thiab 1-hloov indolactam precursors.
4. Cov kws tshawb nrhiav siv 1-Methyl-D-tryptophan CAS 110117-83-4 hauv kev tsim cov tshuaj PET cov tshuaj tshiab (xws li 1-methyl-D-D- DO tu-Turp-[13}} DO-tu, TRp-[13}) thiab hauv kev tshawb fawb soj ntsuam chiral inversion mechanisms qhov twg D-MT hloov mus rau L-MT hauv vivo ntawm D-amino acid oxidase .

1. 1-Methyl-D-tryptophan yuav tsum muab khaws cia rau hauv lub thawv kaw nruj nreem nyob rau hauv qhov chaw txias, qhuav, thiab zoo- qhov cua nyob rau hauv qhov chaw tsis muaj roj (nitrogen lossis argon), tiv thaiv lub teeb thiab huab cua vim nws yog lub teeb thiab huab cua rhiab heev.
2. Pom zoo cia tej yam kev mob: hmoov daim ntawv yog ruaj khov mus txog 3 xyoo ntawm -20℃los yog 2 xyoo ntawm 4 degree; Lub sij hawm luv luv ntawm 0-4℃tau txais, thaum cov kev daws teeb meem hauv DMSO tuaj yeem khaws cia ntawm -20℃txog li 1 lub hlis; Qee qhov chaw pom zoo kom chav tsev kub cia hauv qhov chaw txias, tsaus nti hauv qab 15 degree.
3. 1-Methyl-D-tryptophan CAS 110117-83-4 yog cais nrog GHS cov nqe lus txaus ntshai H315 (Ua rau tawv nqaij khaus), H319 (Ua rau qhov muag khaus), thiab H335 (Tej zaum ua rau ua pa ua pa), nrog cov lus ceeb toom "Warning"; Nws muaj teeb meem yog tias nqos tau thiab tuaj yeem ua rau khaus rau qhov muag, tawv nqaij, thiab ua pa.
4. Cov neeg ua haujlwm yuav tsum hnav cov tshuaj lom neeg- cov hnab looj tes tiv thaiv (nitrile roj hmab), nruj nruj looj tsom iav nrog sab- cov ntaub thaiv npog, thiab cov khaub ncaws tiv thaiv thaum tuav cov khoom no, zam kev tsim cov plua plav thiab aerosols, ua kom muaj cua txaus, thiab ua raws li cov lus qhia ceev faj P261, P280 P305+P351+P338 .

1. Tshem tawm ntawm qhov chaw nchuav, xyuas kom muaj qhov cua txaus, thiab hnav cov khoom tiv thaiv tus kheej nrog rau cov tshuaj lom neeg- cov hnab looj tes tiv thaiv, tsom iav tiv thaiv, thiab lub tshuab ua pa uas tsim nyog (hom N95 lossis P1 lim) thaum 1-methyl-D-tryptophan raug tso tawm, tshem tawm cov neeg ua haujlwm tsis raug.
2. Sau 1-Methyl-D-tryptophan CAS 110117-83-4 los ntawm kev cheb lossis nqus tsev yam tsis tsim cov plua plav siv cov cuab yeej tsis ua kom tawg, lossis nqus nrog cov khoom siv tsis zoo xws li diatomite lossis universal binders, thiab muab tso rau hauv cov thawv kaw tsim nyog rau kev pov tseg.
3. Tsis txhob tsim cov huab cua thaum lub sij hawm ntxuav kom tsis txhob ua pa; decontaminate nto siv txoj kev tsim nyog; tiv thaiv cov khoom los ntawm kev nkag mus rau hauv cov dej ntws los yog cov dej hauv chav dej raws li kev tso tawm mus rau ib puag ncig yuav tsum zam (WGK Lub Tebchaws Yelemees 3 - dej txaus ntshai).
4. Tshem tawm cov khoom pov tseg raws li cov khoom pov tseg uas muaj kev phom sij raws li hauv zos, xeev, thiab tsoomfwv cov cai tswjfwm ib puag ncig los ntawm kev tso cai ua kom puas tsuaj lossis tswj kev tua hluav taws; Nco ntsoov tias cov khoom no tsis raug tswj raws li cov khoom txaus ntshai rau kev thauj mus los (IATA, IMO, RID / ADR).

1. 1-Methyl-D-tryptophan yog combustible nrog ib tug flash point ntawm kwv yees li 213.4 degree, melting point ntawm 242-245 degree, thiab boiling point ntawm 429.3℃ntawm 760 mmHg; Nyob rau hauv cov xwm txheej hluav taws kub, cov khoom puas tsuaj muaj xws li cov pa roj carbon monoxide, carbon dioxide, thiab nitrogen oxides (NOx).
2. Siv cov hmoov qhuav qhuav, carbon dioxide, cawv- ua npuas dej resistant, los yog dej tshuaj tua hluav taws uas muaj cov khoom; Tsis txhob siv lub dav hlau dej ncaj qha raws li 1-Methyl-D-tryptophan CAS 110117-83-4 tuaj yeem tawg cov khoom tawg.
3. Cov neeg tua hluav taws yuav tsum hnav nws tus kheej- muaj cov cuab yeej ua pa hauv siab- thov, MSHA/NIOSH tau pom zoo, thiab cov iav tiv thaiv tag nrho thaum tuav cov kub hnyiab 1-methyl-D-tryptophan vim yog cov pa phem uas tsim los ntawm thermal decomposition .
4. Thaum lub sij hawm combustion, tej zaum yuav emit irritant thiab toxic fumes; txav cov thawv los ntawm qhov chaw tua hluav taws yog tias muaj kev nyab xeeb ua li ntawd, txias cov thawv ntim nrog cov tshuaj tsuag dej los ntawm qhov chaw tiv thaiv, thiab muaj cov hluav taws kub los tiv thaiv ib puag ncig thiab muaj kuab paug.