Thaum kawg ntawm lub xyoo pua puv 19, kev lag luam tsim cov calcium carbide los ntawm hluav taws xob rauv txoj kev pib, uas tsim cov xwm txheej rau kev sib txuas ntawm cov khoom siv organic los ntawm acetylene nrog thee ua cov khoom siv raw. Nyob ib ncig ntawm xyoo 1910, kev tsim khoom lag luam ntawm tetrachloroethane, trichloroethylene, acetaldehyde, acetic acid, thiab lwm yam los ntawm acetylene tau pom hauv lub teb chaws Yelemees, thiab tom qab ntawd lwm cov khoom tsim los ntawm acetylene tau ua tiav rau hauv lub teb chaws Yelemees ua ntej Tsov Rog Ntiaj Teb Zaum Ob. Lwm txoj hauv kev tseem ceeb siv cov thee ua cov khoom siv raw yog los tsim cov khoom siv organic los ntawm syngas lossis carbon monoxide. Kev vam meej synthesis ntawm methanol nyob rau hauv lub teb chaws Yelemees nyob rau hauv 1923 pib txoj kev loj hlob keeb kwm ntawm kev siv syngas raws li ib tug industrial hluavtaws raw khoom. Nrog rau txoj kev loj hlob ntawm cov roj av refining kev lag luam, kev siv roj av hydrocarbon raw cov ntaub ntawv los synthesize organic khoom tau attracting xim. Ntawm qhov tod tes, pib los ntawm cov roj av hydrocarbons, kev tsim khoom lag luam tau ua tiav tiav los ntawm cov txheej txheem ntawm kev tawg olefins, acetylene thiab hloov mus rau hauv cov roj synthesis; ntawm qhov tod tes, txij li thaum lub synthesis ntawm isopropanol los ntawm propylene tau muab tso rau hauv industrial ntau lawm nyob rau hauv 1920, organic Cov hluavtaws kev lag luam tau zoo heev tsim tsis tu ncua. Cov saum toj no qhia tau hais tias cov organic chemical kev lag luam tau hloov pauv los ntawm cov thee ua cov khoom siv raw rau roj av hydrocarbons raws li cov khoom siv raw, thiab los ntawm kev sib xyaw ntawm acetylene mus rau synthesis ntawm olefins ua raw khoom. Feem ntau hais lus, ib feem loj lossis ib feem tseem ceeb ntawm kev lag luam organic tshuaj lom neeg kuj feem ntau hu ua kev lag luam petrochemical.
